New saponin 26-O-tert-butyldimethylsiliyl protodiosgenyl β-D-glucopyranoside 1 was synthesized and its cytotoxicity activity in vitro was evaluated by MTI＇. It showed potent antitumor activity to human cancer cells. E ring and C22-OH play important roles in the antitumor activity of 1. A method to selective removal of acetyl group in the presence of benzoyl group was reported.
Liang ZHOU Shu Jie HOU Peng XU De Quan YU Ping Sheng LEI Chuan Chun ZOU
Using orthogonal protection-deprotection glycosylation strategy, a series of diosgenyl glycosides with same of monosaccharides component but different in sequence were synthesized. The antitumor activity in vitro of synthesized diosgenyl glycosides was evaluated by standard MTT assay. It was observed that diosgenyl glycosides with a rhamnopyranosyl at C2′ of glucopyranosyl residue show potent antitumor activity in vitro.
Shu Jie Hou Chuan Chun Zou Liang Zhou Peng Xu De Quan Yu Ping Sheng Lei
One of the analogues of icogenin, a natural furostanol saponin showing strong cytotoxic effect on cancer cell, was first synthesized via convergent strategy by using diosgenin and available monosaccharides as starting materials.
Shu Jie HOUPeng XULiang ZHOUDe Quan YUPing Sheng LEIChuan Chun ZOU
Two tigogenyl glycosides containing N-acetylglucosamine were synthesized. Their structures were confirmed by ^1H and ^13C NMR spectra. The shielding effect caused by benzoyl groups was elucidated by ^1H NMR, COSY, HSQC, HMBC spectroscopy.
