The compression behavior of a natural hydroxyapophyllite is investigated up to about 10.01 GPa at 300 K using in situ angle-dispersive X-ray diffraction and a diamond anvil cell at the High Pressure Experiment Station, Beijing Synchrotron Radiation Facility (BSRF). Over this pressure range, no phase change or disproportionation is observed. The isothermal equation of state is determined for the first time. The values of zero-pressure volume V0 , isothermal bulk modulus K0 , and K0 refined with a third-order Birch-Murnaghan equation of state are V0 = 1276.3±0.9 3 , K0 = 71±3 GPa, and K0 = 8±1. Furthermore, we confirm that the values of linear compressibility β along the a and c directions of hydroxyapophyllite are elastically anisotropic.