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国家自然科学基金(30872165)

作品数:6 被引量:27H指数:4
相关作者:米杰张美仙赵小元丁秀原席波更多>>
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Abnormal Adipokines Associated with Various Types of Obesity in Chinese Children and Adolescents被引量:4
2011年
Objective To explore the role of adipokines including insulin, resistin, leptin, adiponectin, acylation stimulating protein (ASP) and complement C3 (C3) in various types of obesity (peripheral obesity, abdominal obesity and mixed obesity) in Chinese children and adolescents, and their relationships with body size and pubertal development. Methods Children and adolescents (n=3 508) aged 6 to 18 years, with 1 788 boys and 1 720 girls were assessed for body mass index, waist circumference, pubertal development, blood insulin, resistin, leptin, adiponectin, ASP and C3 levels. Three types of obesity [peripheral obesity (n=43), abdominal obesity (n=473), mixed obesity (n=1 187)] and non‐obese control (n=1 805) were defined with combined use of Chinese body mass index and waist circumference criteria. Results Serum resistin, leptin and adiponectin levels were higher in girls than those in boys (all P0.01). Insulin and leptin increased and adiponectin decreased across five Tanner stages in both girls and boys (all P0.001), while ASP changed only in girls (P0.001) and C3 only in boys (P0.001). Insulin, leptin and ASP were higher, but adiponectin was lower in all three types of obesity vs. the non‐obese control (all P0.05). The greatest abnormalities of all six adipokines were found in the mixed obesity group. With inclusion of body mass index and waist circumference in simultaneous regression analyses, both body size indices were independently and significantly correlated with insulin, leptin and adiponectin after age and gender adjustment. Compared with waist circumference, the body mass index was stronger in interpreting insulin, leptin, adiponectin and ASP levels, whereas it was weaker in explaining variance of plasma C3. Conclusions Obese children have a worse metabolic profile with high insulin, resistin, leptin, ASP and C3, and low adiponectin levels. The adipokine profile in mixed obesity is worse than that in peripheral or abdominal obesity. Identification of
ZHANG MeiXianZHAO XiaoYuanLIMingCHENG HongHOU DongQingWEN YuKatherine CIANFLONEMI Jie
关键词:ADIPOKINECHINESE
体脂和肥胖相关基因多态性与生活行为因素交互作用对学龄儿童肥胖的影响被引量:3
2010年
目的 探讨体脂和肥胖相关基因(FTO)多态性与生活行为因素的交互作用对学龄儿童肥胖的影响.方法 从"北京市儿童青少年代谢综合征(BCAMS)研究"中选取6~18岁学龄儿童3503名,分为肥胖组(1229名)和非肥胖组(2274名).进行问卷调查、静脉采血和基因型检测.结果 采用因子分析方法,共提取蛋白类食物、果蔬、烟酒、静态生活方式和业余体育活动5个公因子.logistic回归分析显示,以FTO基因与蛋白类食物交互作用为例,当两因素共同存在时,其中归因于交互作用的危险度占19.16%.该位点多态性与果蔬、静态生活方式和业余体育活动的交互作用归因百分比则依次为5.97%、19.62%和12.43%;该位点与烟酒可能不存在交互作用.结论 在中国学龄儿童中,蛋白类食物、果蔬、静态生活方式和业余体育活动等生活行为因素可能修饰FTO基因与肥胖的关系.但仍需要大规模、前瞻性的干预性研究,验证FTO基因与环境因素的交互作用对儿童肥胖的真实影响.
席波张美仙沈玥赵小元王兴宇米杰
关键词:肥胖生活行为因素
肥胖全基因组关联研究的现状与展望被引量:4
2010年
常见复杂性疾病,又称多基因疾病,是由多对微效基因与环境因素共同作用所致,具有明显的遗传异质性、表型复杂性及种族差异性等特征.常见复杂性疾病和单基因疾病的一个最显著的区别是,它不依照经典的孟德尔模式遗传.伴随着生活环境的改变,发展中国家正经历着流行病由过去严重传染性疾病向常见慢性疾病的转移[1].以肥胖为例,1980-2002年期间,美国20岁以上成年人的肥胖率增加了1倍 6~19岁儿童青少年的超重率增加了2倍[2].2006年世界卫生组织(WHO)数据显示,世界肥胖人群已逾4亿[3].
席波米杰
关键词:肥胖全基因组关联研究
Reduced Arterial Compliance Associated with Metabolic Syndrome in Chinese Children and Adolescents被引量:3
2010年
Objective To explore the metabolic syndrome and its association with arterial compliance in Chinese children and adolescents. Methods 337 participants aged 6 to 18 years with males accounted for 55.8% were grouped according to their traits of metablic syndrome. Anthropometry, blood pressure, fasting plasma glucose, insulin and serum lipid profile were measured. Homeostasis model was assessed and insulin resistance (HOMA-IR) index was measured and calculated for estimating individual insulin resistance. Arterial compliance was also measured using digital pulse wave analyzing method (Micro medical, London), and stiffness index was calculated. Results The stiffness index in participants with metablic syndrome was significant higher than that in participants with no riskof metablic syndrome [(7.69±1.63) vs (6.25±0.86) m/s, P〈0.01] and stiffness index and HOMA-IR were progressively increased with the increase of traits of metablic syndrom (P for linear trend 〈0.001). After gender, age, and pubertal development were adjusted, both traits of metablic syndrome and HOMA-IR were correlated positively with stiffness index (both P〈0.05). Conclusion The clustering of metablic syndrome was closely associated with risk at increased arterial stiffness in Chinese children and adolescents. It was suggested that arterial compliance assessment of children and adolescents might be an important measure for prevention of cardiovascular diseases.
BO XILI ZHANGJIE MI
肥胖及伴非酒精性脂肪肝病儿童血清脂联素与代谢综合征的相关性被引量:6
2009年
目的研究肥胖及伴非酒精性脂肪肝病(NAFLD)儿童、青少年的血脂代谢特征及血清脂联素水平与代谢综合征(MS)的关系。方法采用典型整群抽样方法选取北京市海淀区中等水平的4所小学和4所中学的7~18岁儿童及青少年,在知情同意的前提下,进行问卷、身体测量、腹部B超脂肪肝检查及血生化检测。从中选取各项调查资料完整的609例作为研究对象,其中单纯肥胖儿童280例,肥胖伴NAFLD儿童65例(肥胖伴NAFLD组),正常体质量儿童264例作为健康对照组。经统计分析,正态分布测量数据以x-±s表示;血清三酰甘油(TG)、脂联素、ALT和AST生化指标呈偏态分布,以几何均数和四分位间距(P25~P75)表示,经自然对数转化为正态分布后进行分析。采用方差分析、Logistic回归分析等。结果肥胖组及肥胖伴NAFLD组体质量指数(BMI)及腰围(WC)显著高于健康对照组,3组间差异有统计学意义(P<0.001);3组儿童的空腹血浆葡萄糖、血脂、脂联素及转氨酶水平比较差异均有显著统计学意义;肥胖伴NAFLD组儿童的ALT、AST明显升高;控制可能的影响因素年龄、性别后进行多因素Logistic回归分析显示,与单纯肥胖组比较,肥胖伴NAFLD组MS及组分高TG、高血压的检出率明显增加,罹患MS的相对风险增加尤为显著(P<0.001)。结论肥胖及肥胖伴NAFLD对儿童、青少年的肝功能和血脂代谢均造成危害,其血清脂联素水平随肥胖程度的增加而降低,脂联素作为胰岛素的增敏激素,连接脂肪组织和整体糖代谢,脂联素可作为MS的评估指标之一。
赵小元丁秀原孟铃慧张美仙米杰
关键词:肥胖非酒精性脂肪肝病脂联素儿童
儿童青少年脂肪细胞因子与肥胖度的关系研究被引量:7
2010年
目的探讨儿童青少年血中胰岛素、瘦素、脂联素和抵抗素水平与肥胖程度的关系。方法选择2004年北京市儿童青少年代谢综合征(BCAMS)调查总样本中的3511例(男1790例,女1721例)6~18岁儿童青少年为研究对象,依据体重指数值分类标准将所有研究对象分为正常体重组1626例、超重组655例和肥胖组1230例。利用酶联免疫吸附试验法(ELISA)检测研究对象空腹血脂肪细胞因子水平。采用协方差分析比较超重组、肥胖组与正常体重组间脂肪细胞因子的差异;不同肥胖程度对预测脂肪细胞因子异常的作用采用多因素Logistic回归分析。结果超重、肥胖组儿童血中胰岛素、瘦素水平高于正常体重组,并随着肥胖程度的增加而升高,且具有明显的男女性别差异;脂联素水平则随着肥胖程度的增加而降低;抵抗素水平仅见肥胖组与正常体重组儿童比较差异有统计学意义。采用多因素Logistic回归模型调整年龄、性别和青春发育期,以正常体重组为参照,进行对比分析。结论儿童青少年血中胰岛素、瘦素、脂联素水平与肥胖程度密切相关,脂肪细胞因子异常检出率随着体重的增加而升高,因此,在儿童青少年时期控制体重、降低肥胖程度对预防"儿童成人慢性病"至关重要。
程红丁秀原张美仙赵小元米杰
关键词:儿童青少年肥胖脂肪细胞因子代谢综合征
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