Nanoporous metals(NPMs) show potential applications as enzyme-free glucose sensors.There are few reports on nanoporous Pd in this area even though their cost is much lower than other NPMs.In this work,we report the formation of Pd-based NPM with improved catalytic activity towards the oxidation of glucose.By dealloying metallic glasses,Pd-based NPMs with bi-continuous networks were obtained.All the Pd-based NPMs show high electrochemical catalytic activity towards glucose oxidation.In this study,NPM with an open,three-dimensional,ligament-channel nanoporous structure resulted by dealloying metallic Pd_(30)Cu_(40)Ni_(10)P_(20).producing a pore size of 11 nm and a ligament size of 7 nm as the best configuration towards the direct oxidation reaction of glucose.