The palladium/copper-cocatalyzed oxidative C-H/C-H cross-coupling between two heteroarenes by using molecular oxygen as an oxidant instead of metal oxidants has been developed for the first time to construct biheteroaryl motifs.A relatively broad range of thiophenes,furans and indoles can smoothly couple with various N-heteroarenes in satisfactory yields.This catalytic system with O2 as the terminal oxidant offers clear advantages of economically feasible and eco-friendly processes.
Yang ShiZhen WangYangyang ChengJingbo LanZhijie SheJingsong You
