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国家自然科学基金(10771163)

作品数:10 被引量:7H指数:2
相关作者:刘妍岩刘维钊杨延召马成刚杨丹更多>>
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10 条 记 录,以下是 1-10
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基于DNA微阵列数据分析的分级Bayes模型
2009年
如何分离出少量区别不同组织类型的特异性基因是DNA微阵列数据分析中的主要问题,特别是构建恰当的统计模型来刻画这些不同组织类型的DNA表达形式尤为重要.为此,基于基因DNA微阵列数据的特点,我们假定对数变换后的微阵列数据服从混合正态分布.我们采用分级Bayesian先验刻画不同基因的相关性,利用分级Bayesian方法构建模型,给出了刻画不同组织基因表达的差异的一个标准,用MCMC迭代计算该标准.模拟计算表明我们的模型具有较好的识别能力.
刘妍岩杨丹
关键词:BAYES推断DNA基因表达微阵列
ψ-混合相依变量线性形式的强稳定性(英文)被引量:2
2011年
线性形式的强稳定性在科学技术上存在着广泛应用. 本文讨论了ψ-混合随机变量列线性形式的强稳定性.通过对ψ-混合随机变量列运用截尾术, 借助于ψ-混合随机变量的性质以及Borel-Cantelli引理, 得到了ψ-混合随机变量线性形式具有强稳定性的充分条件. 同时也给出了一些其它形式的结果.
杨延召刘妍岩
关键词:强稳定性Ψ-混合
遗传参数的极大似然估计
2009年
将Luo和Woolliams模型中的混合正态分布推广到混合对数正态分布,先用矩量法得到各参数的估计值,再将此估计值作为EM(Expectation Maximization)算法迭代的初值进行迭代,将矩量估计和极大似然估计结合起来,提高了EM算法的收敛速度并使修改后的模型更符合生物学事实.
张晴霞刘妍岩
关键词:极大似然估计数量性状基因位点标记基因
分层关联表中伞形序对无约束问题的检验
2009年
概率分布间的随机序是应用概率论与统计推断中的一个重要概念.基于交叉分类数据的趋势检验问题已被广泛地研究,并且分层关联表广泛存在于实践中.似然比检验方法常用于涉及随机序约束问题的检验.对带序约束的分层关联表,该文介绍了一种不基于模型假定的似然比检验方法,并且给出了检验统计量的极限分布.
冯艳钦邱小霞马成刚
关键词:随机序Χ^2分布似然比检验关联表
Consistency of the Estimator of Cumulative Hazard Function in Estimated Pseudo-Partial-Likelihood Approach
2009年
For multivariate failure time with auxiliary covariate information, an estimated pseudo-partial-likelihood estimator under the marginal hazard model with distinguishable baseline hazard has been proposed. However, the asymptotic properties of the corresponding estimated cumulative hazard function have not been studied. In this paper, based on counting process martingale, we use the continuous mapping theorem and Lenglart inequality and prove the consistency of the estimated cumulative hazard function in estimated pseudo-partial-likelihood approach.
LIU Yanyan,YUAN Zhongshang School of Mathematics and Statistics,Wuhan University,Wuhan 430072,Hubei,China
关键词:CONSISTENCY
一个新的复合极值分布被引量:2
2013年
提出了一个新的具有单调降危险率的厚尾分布,该分布通过"混合"Pareto分布和Poisson分布而成,是一种复合极值分布。导出了新分布的概率统计特性,研究了各种可应用于风险分析和可靠性工程的特征量(包括矩、熵、危险率函数、平均剩余寿命等),获得了未知参数极大似然估计的存在唯一性。数值模拟表明该极大似然估计具有良好的有限样本性质。
刘维钊
关键词:PARETO分布POISSON分布极值分布极大似然估计
Semiparametric Additive Intensity Model with Frailty for Recurrent Events被引量:1
2011年
The seminal Cox's proportional intensity model with multiplicative frailty is a popular approach to analyzing the frequently encountered recurrent event data in scientific studies. In the case of violating the proportional intensity assumption, the additive intensity model is a useful alternative. Both the additive and proportional intensity models provide two principal frameworks for studying the association between the risk factors and the disease recurrences. However, methodology devel- opment on the additive intensity model with frailty is lacking, although would be valuable. In this paper, we propose an additive intensity model with additive frailty to formulate the effects of possibly time-dependent covariates on recurrent events as well as to evaluate the intra-class dependence within recurrent events which is captured by the frailty variable. The asymptotic properties for both the regression parameters and the association parameters in frailty distribution are established. Fhrthermore, we also investigate the large-sample properties of the estimator for the cumulative baseline intensity function.
Yah Yah LIU Yuan Shan WU
关键词:FRAILTY
Maximum Likelihood Estimator for the Proportional Hazards Model with Incomplete Information
2012年
Right randomly censored data with incomplete infor-mation are frequently met in practice.Although much study about right randomly censored data has been seen in the proportional hazards model,relatively little is known about the inference of regression parameters for right randomly censored data with in-complete information in such model.In particular,theoretical properties of the maximum likelihood estimator of the regression parameters have not been proven yet in that model.In this paper,we show the consistency and asymptotic normality of the maxi-mum likelihood estimator of unknown regression parameters.
CHEN YurongLIU Luqin
Statistical Inference for Simple Tree Order in the Means of Stochastic Order on Stratified Contingency Tables
2010年
In this paper, we consider testing the hypothesis that all multinomial populations in the stratified contingency table are identically distributed against the alternative that all these popula- tions are in simple tree order. We provide an asymptotic represen- tation of the order-restricted maximum likelihood estimate of the unknown parameters. The resulting estimators are proven to be ~n-consistent and asymptotically normal under appropriate conditions. A chi-squared test method is used for this hypothesis test problem. A real data set is applied to illustrate our theoretical result.
YAN Guoyi1,2, CHEN Jingjing3 1.School of Mathematics and Statistics, Wuhan University, Wuhan 430072, Hubei, China
A LAW OF ITERATED LOGARITHM FOR THE MLE IN A RANDOM CENSORING MODEL WITH INCOMPLETE INFORMATION被引量:2
2008年
In this article, a law of iterated logarithm for the maximum likelihood estimator in a random censoring model with incomplete information under certain regular conditions is obtained.
宋凤丽刘禄勤
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