合成了2-羟基萘醛苯乙酰腙(1)、2-羟基萘醛-4-羟基苯乙酰腙(2)和2-羟基萘醛-2-甲氧基苯乙酰腙(3)三种新型酰腙化合物,通过单晶X射线衍射(XRD)、元素分析和傅里叶变换红外(FTIR)光谱对化合物结构进行了表征。单晶X射线衍射结果表明,化合物2和3结晶为单斜晶系,空间群C2/c。而化合物1结晶为正交晶系,空间群为Pbca。热重(TG)分析结果表明,化合物1、2、3分子骨架热分解的温度分别为318.23、319.04、323.01°C,对应的热分解过程表观活化能分别为115.90、145.18、129.38 k J?mol-1。微量热研究表明,三种酰腙及其前驱体酰肼与小牛胸腺脱氧核糖核酸(CT-DNA)相互作用均为吸热作用,但作用时间(1.00-50.0 min)和反应熵变(0.47-15.50 k J?mol-1)有较大的差异。化合物1和2与CT-DNA的反应焓变均大于其前驱体酰肼a和b与CT-DNA的反应焓变,而化合物3与CT-DNA的反应焓变却小于其前驱体酰肼c与CT-DNA的反应焓变。
The chelate complex of Cu2+ with 2-hydroxy-(4-methylthio)butanoate(MHA-H, the anion derived from the so-called methionine hydroxy-analogue, largely used in animal nutrition as a source of methionine, MHA) is an efficient, bioavailable trace mineral additive for animal feeding. The structure of MHA-H copper chelate was investigated by single-crystal X-ray diffraction. The crystal structure(C10H18Cu O6S2, 1, monoclinic, space group P21/c, Z = 2, a = 16.158(4), b = 4.9733(12), c = 9.159(2) ?, β = 104.786(4)°) exhibits that two MHA-H ligands coordinate with a CuII ion to form a square-planar environment completed to an octahedron through interaction with carbonyl oxygens of neighboring molecules, which expand to constitute a two-dimensional sheet coordination network. And a separation between the hydrophilic and lipophilic moieties like micelles was found in the packing structure. X-ray powder diffraction and thermogravimetric analysis were used to study the phase purity of the bulk sample and thermostability of complex 1, respectively.
