An approach combining optimal antenna subset selection with blind detection scheme for Orthogonal Space-Time Block Coding (OSTBC) is proposed in this paper. The optimal antenna sub- set selection is taken into account at transmitter and/or receiver sides, which chooses the optimal an- tennas to increase the diversity order of OSTBC and improve further its performance. In order to en- hance the robustness of the detection used in the conventional OSTBC scheme, a blind detection scheme based on Independent Component Analysis (ICA) is exploited which can directly extract transmitted signals without channel estimation. Performance analysis shows that the proposed ap- proach can achieve the full diversity and the flexibility of system design by using the antenna selec-tion and the ICA based blind detection schemes.