A convenient protocol has been developed for the hydrogenation of metallo-protoporphyrin IX dimethyl esters （MPPDMEs） to their mesoporphyrin analogues using CoC12-NaBH4 reagent system. Metallo-porphyrin complexes were found to perform as self-catalysts in this procedure. This method provides several advantages such as safe and simple procedure, short reaction time, high yields and low cost.
A novel thiol-derivative porphyrin[2,7,12,18-tetramethyl-13,17-di（3-disulfidepropyl）porphyrin]bearing the symmetrical disulphide bond and its metal complexes have been successfully prepared by means of modification on naturally easily derived heme.The results are described by MS-MS and UV-vis spectroscopy.
Cheng Guo Sun Bing Cheng Hu Wei You Zhou Shi Chao Xu Quan Zhi Deng Zu Liang Liu
以氯化血红素(1)为原料,经过加成和取代反应制得血卟啉(2)。然后在超声波激励下,以血卟啉(2)作为原料,浓硫酸作为催化剂,甲醇既作溶剂又作反应剂,合成了[2,7,12,18-四甲基-3,8-(-1-羟基乙基)-13,17-二甲氧基羰基乙基]-卟啉(血卟啉二甲酯,3),两步反应总产率达到74.8%。探讨了反应时间、催化剂用量以及超声功率对血卟啉二甲酯(3)合成的影响,并且将超声波激励法与加热搅拌法进行了比较。实验结果表明,同加热搅拌法相比,超声激励法反应时间更短,产率更高,副产物更少。产物结构通过1 H NMR、MS和IR测试技术进行了表征。
