We present a novel efficient approach in calculating induced transmembrane voltage（ITV） on cells based on transformation optics. As cell membrane is much thinner than the dimension of a typical cell, discretizing the membrane needs numerous meshes. Using an anisotropic medium based on transformation optics, the thickness of the membrane can be exaggerated by at least one order, which eliminates rigorous mesh refinement and reduces unknowns greatly. The accuracy and efficiency of the proposed method are verified by a cylindrical cell model. Moreover, the influence on ITV with bound water（BW） layers is also studied. The results show that when cells are exposed to nanosecond electric field, BW layers should be rigorously considered in calculating ITV.
