Conjugated linoleic acids(CLAs) are a generic term for linoleic acid isomers and have a variety of biological functions. After rat preadipocytes were incubated in CLAs-supplemented media,their proliferation and differentiation were observed by the cell count and the oil red O staining. The results showed that the CLAs at different concentrations inhibited proliferation of the rat preadipocytes in a time-and dose-dependent manner. And the CLAs greatly decreased intracellular lipid content in mature adipocytes. Moreover,lipogenesis was inhibited by the CLAs in a dose-dependent manner. Therefore,the CLAs inhibit the lipogenesis by reducing the number of preadipocytes and decreasing the intracellular lipid content.
